Alpha Synuclein: Research Products
StressMarq Biosciences is a bioreagents company offering antibodies, proteins, ELISA kits, and small molecules for the life sciences research sector. They have developed a range of fibrilized and oligomeric protein preparations for use in neurodegenerative disease research, including alpha synuclein, amyloid beta, tau, SOD1 and TTR. StressMarq is a world leader in the development and supply of fibrilized proteins (and their derivatives), protein oligomers, and antibodies to these constructs to assist researchers studying Alzheimer’s, Parkinson’s, and other neurodegenerative diseases.
Alpha Synuclein Antibodies
StressMarq’s complete antibody portfolio is available conjugated to Alkaline Phosphatase, HRP, and Biotin, as well as 7 fluorescent dyes.
Alpha Synuclein Proteins
Alpha Synuclein Pre-formed Fibrils (PFFs)
StressMarq’s alpha synuclein pre-formed fibrils (PFFs) seed the formation of new fibrils from active alpha synuclein monomers, and can be used to induce endogenous alpha synuclein phosphorylation and subsequent Lewy body inclusion formation in neuronal cell culture or for in vitro oligomerization studies.
| Product Description | Catalog# | Monomer Source |
|---|---|---|
| Human Alpha Synuclein Pre-formed Fibrils (Type 1) | SPR-322 | Human Alpha Synuclein Monomers, catalog# SPR-321 |
| Human Alpha Synuclein Pre-formed Fibrils (ATTO 594 conjugated, Type 1) | SPR-322-A594 | Human Alpha Synuclein Monomers, catalog# SPR-321 |
| Mouse Alpha Synuclein Pre-formed Fibrils (Type 1) | SPR-324 | Mouse Alpha Synuclein Monomers, catalog# SPR-323 |
| Human Alpha Synuclein Pre-formed Fibrils (Type 2) | SPR-317 | Human Alpha Synuclein Monomers (Type 2), catalog# SPR-316 |
| Human Alpha Synuclein N-Terminal Acetylated Pre-formed Fibrils (Type 1) | SPR-332 | Human N-Terminal Acetylated Alpha Synuclein Monomers, catalog# SPR-331 |
| Human Alpha Synuclein A53T Mutant Pre-formed Fibrils (Type 1) | SPR-326 | Human A53T Alpha Synuclein Monomers (Type 1), catalog# SPR-325 |
| Rat Alpha Synuclein Pre-formed Fibrils | SPR-482 | Rat Alpha Synuclein Monomers, catalog# SPR-481 |
| Human Alpha Synuclein Filaments (Immature Fibrils) | SPR-450 | Human Alpha Synuclein Monomers, catalog# SPR-321 |
Alpha Synuclein Oligomers
Alpha synuclein oligomers are increasingly thought to be the toxic species in synucleinopathies. StressMarq’s kinetically stable alpha synuclein oligomers are toxic to dopaminergic neurons and induce phosphorylation of alpha synuclein Ser129 (a pathology associated with Parkinson’s disease), and are generated without the addition of any inducers or inhibitors. StressMarq also offers dopamine-stabilized alpha synuclein oligomers and EGCG-stabilized alpha synuclein oligomers. Dopamine and EGCG can be used to stabilize alpha synuclein in its oligomeric forms, preventing further aggregation into fibrils.
| Product Description | Catalog# | Monomer Source |
|---|---|---|
| Human Alpha Synuclein Oligomers (Kinetically Stable) | SPR-484 | Human Alpha Synuclein Monomers (Type 2), catalog# SPR-316 |
| Human Alpha Synuclein Oligomers (Dopamine HCl Stabilized) | SPR-466 | Human Alpha Synuclein Monomers (Type 2), catalog# SPR-316 |
| Human Alpha Synuclein Oligomers (EGCG Stabilized) | SPR-469 | Human Alpha Synuclein Monomers (Type 2), catalog# SPR-316 |
Alpha Synuclein Monomers
StressMarq’s alpha synuclein monomers are capable of aggregation and do not show neurodegenerative activity.
