Alpha Synuclein: Research Products

StressMarq Biosciences is a bioreagents company based in beautiful Victoria, British Columbia, Canada, that offers a wide range of products for scientists in neuroscience research areas. With a small but dedicated group of scientists, StressMarq provides highly-validated products that are supported by years of scientific expertise. With recently launched alpha synuclein and tau protein preformed fibrils, StressMarq supplies cutting-edge research tools for neurodegenerative disease such as Alzheimer’s and Parkinson’s.

Alpha Synuclein Antibodies

 

Monoclonal Polyclonal
Alpha Synuclein Antibody, Clone 3C11  Alpha Synuclein Antibody (pSer129)
Alpha Synuclein Antibody, Clone 10H7  Alpha Synuclein Antibody (pTyr136)
 Alpha Synuclein Antibody, Clone 3F8
 Alpha Synuclein Antibody, Clone 4F1
 Alpha Synuclein Antibody, Clone J18

StressMarq’s complete antibody portfolio is available conjugated to Alkaline Phosphatase, HRP, Biotin, and Streptavidin as well as 13 fluorescent dyes.

Alpha Synuclein Proteins

StressMarq offers a wide variety of alpha synuclein protein monomers, oligomers, fibrils, and filaments. This table summarizes the differences between them.

Catalog No Protein Species Mutant Monomer source Endotoxin Thioflavin T Activity* Primary Cells Activity In Vivo Activity
SPR-322 Type 1 PFFs Human Wild-type SPR-321 10-20 EU/mL >12 000 fluorescent units when combined with SPR-321 monomer. 1300 fluorescent units when combined with SPR-316 monomer Induces alpha synuclein phosphorylation and Lewy body pathology in primary rat and mouse neurons Induces alpha synuclein pathology within 30 days of injection into rat brain
SPR-322-A594 ATTO 594-Conjugated Type 1 PFFs Human Wild-type SPR-321 10-20 EU/mL >21 500 fluorescent units when combined with SPR-321 monomer. Under Investigation Under Investigation
SPR-324 Type 1 PFFs Mouse Wild-type SPR-323 10-20 EU/mL > 3100 fluorescent units when combined with SPR-323 monomer Induces alpha synuclein phosphorylation and Lewy body pathology in primary rat neurons and primary mouse neurons Induces alpha synuclein pathology within 30 days of injection into rat brain.
SPR-326 Type 1 PFFs Human A53T SPR-325 10-20 EU/mL 28 000 fluorescent units when combined with SPR-325 monomer Induces alpha synuclein phosphorylation and Lewy body pathology in primary rat neurons Under Investigation
SPR-317 Type 2 PFFs Human Wild-type SPR-316 <2 EU/mL 3000 fluorescent units when combined with SPR-321 monomer. 400 fluorescent units when combined with SPR-316 monomer Does not induce Lewy body pathology in primary rat cells in short-term experiments, but can induce cell death Under Investigation
SPR-448 Type 3 PFFs (Treated with alternative scaffold)1 Human Wild-type SPR-316 <2 EU/mL 1000 fluorescent units when combined with SPR-321 monomer Under investigation Under Investigation
SPR-450 Soluble Filaments2 Human Wild-type SPR-321 10-20 EU/mL Unable to seed SPR-321 monomer (measured by turbidity). Forms insoluble fibrils in 7 days when incubated at 37C with shaking at 700 rpm. Under Investigation Under Investigation
SPR-466 Dopamine-Stabilized Oligomers Human Wild-type SPR-316 <2 EU/mL Under investigation MTT and LDH assays show toxicity in primary mouse neurons Under Investigation
SPR-469 EGCG-Stabilized Oligomers Human Wild-type SPR-316 <2 EU/mL May inhibit seeding of SPR-316 monomer Under investigation Under investigation

*Thioflavin T fluorescent measurements vary based on the equipment used. StressMarq uses a Lumox 96 multiwell plate (Sarstedt Catalog # 94.6000.024) and Molecular Devices Gemini XPS Microplate reader.

 

Parkinson’s Disease Small Molecules

FPS-ZM1

Pinacidil Monohydrate

Rasagiline Mesylate

Tolcapone

Parkinson’s Disease Kits

Nitrotyrosine ELISA Kit

SOD Activity Kit