Alpha Synuclein: Research Products
StressMarq Biosciences is a bioreagents company based in beautiful Victoria, British Columbia, Canada, that offers a wide range of products for scientists in neuroscience research areas. With a small but dedicated group of scientists, StressMarq provides highly-validated products that are supported by years of scientific expertise. With recently launched alpha synuclein and tau protein preformed fibrils, StressMarq supplies cutting-edge research tools for neurodegenerative disease such as Alzheimer’s and Parkinson’s.
Alpha Synuclein Antibodies
StressMarq’s complete antibody portfolio is available conjugated to Alkaline Phosphatase, HRP, Biotin, and Streptavidin as well as 13 fluorescent dyes.
Alpha Synuclein Proteins
StressMarq offers a wide variety of alpha synuclein protein monomers, oligomers, fibrils, and filaments. This table summarizes the differences between them.
|Catalog No||Protein||Species||Mutant||Monomer source||Endotoxin||Thioflavin T Activity*||Primary Cells Activity||In Vivo Activity|
|SPR-322||Type 1 PFFs||Human||Wild-type||SPR-321||10-20 EU/mL||>12 000 fluorescent units when combined with SPR-321 monomer. 1300 fluorescent units when combined with SPR-316 monomer||Induces alpha synuclein phosphorylation and Lewy body pathology in primary rat and mouse neurons||Induces alpha synuclein pathology within 30 days of injection into rat brain|
|SPR-322-A594||ATTO 594-Conjugated Type 1 PFFs||Human||Wild-type||SPR-321||10-20 EU/mL||>21 500 fluorescent units when combined with SPR-321 monomer.||Under Investigation||Under Investigation|
|SPR-324||Type 1 PFFs||Mouse||Wild-type||SPR-323||10-20 EU/mL||> 3100 fluorescent units when combined with SPR-323 monomer||Induces alpha synuclein phosphorylation and Lewy body pathology in primary rat neurons and primary mouse neurons||Induces alpha synuclein pathology within 30 days of injection into rat brain.|
|SPR-326||Type 1 PFFs||Human||A53T||SPR-325||10-20 EU/mL||28 000 fluorescent units when combined with SPR-325 monomer||Induces alpha synuclein phosphorylation and Lewy body pathology in primary rat neurons||Under Investigation|
|SPR-317||Type 2 PFFs||Human||Wild-type||SPR-316||<2 EU/mL||3000 fluorescent units when combined with SPR-321 monomer. 400 fluorescent units when combined with SPR-316 monomer||Does not induce Lewy body pathology in primary rat cells in short-term experiments, but can induce cell death||Under Investigation|
|SPR-448||Type 3 PFFs (Treated with alternative scaffold)1||Human||Wild-type||SPR-316||<2 EU/mL||1000 fluorescent units when combined with SPR-321 monomer||Under investigation||Under Investigation|
|SPR-450||Soluble Filaments2||Human||Wild-type||SPR-321||10-20 EU/mL||Unable to seed SPR-321 monomer (measured by turbidity). Forms insoluble fibrils in 7 days when incubated at 37C with shaking at 700 rpm.||Under Investigation||Under Investigation|
|SPR-466||Dopamine-Stabilized Oligomers||Human||Wild-type||SPR-316||<2 EU/mL||Under investigation||MTT and LDH assays show toxicity in primary mouse neurons||Under Investigation|
|SPR-469||EGCG-Stabilized Oligomers||Human||Wild-type||SPR-316||<2 EU/mL||May inhibit seeding of SPR-316 monomer||Under investigation||Under investigation|
*Thioflavin T fluorescent measurements vary based on the equipment used. StressMarq uses a Lumox 96 multiwell plate (Sarstedt Catalog # 94.6000.024) and Molecular Devices Gemini XPS Microplate reader.