Alpha Synuclein: Research Products

StressMarq Biosciences is a bioreagents company offering antibodies, proteins, ELISA kits, and small molecules for the life sciences research sector. They have developed a range of fibrilized and oligomeric protein preparations for use in neurodegenerative disease research, including alpha synuclein, amyloid beta, tau, SOD1 and TTR. StressMarq is a world leader in the development and supply of fibrilized proteins (and their derivatives), protein oligomers, and antibodies to these constructs to assist researchers studying Alzheimer’s, Parkinson’s, and other neurodegenerative diseases.

Alpha Synuclein Antibodies

Monoclonal Polyclonal
Alpha Synuclein Antibody, Clone 3C11 Alpha Synuclein Antibody (pSer129)
Alpha Synuclein Antibody, Clone 10H7 Alpha Synuclein Antibody (pTyr136)
Alpha Synuclein Antibody, Clone 3F8 Alpha Synuclein Antibody
Alpha Synuclein Antibody, Clone 4F1
Alpha Synuclein Antibody, Clone J18

StressMarq’s complete antibody portfolio is available conjugated to Alkaline Phosphatase, HRP, and Biotin, as well as 7 fluorescent dyes.

Alpha Synuclein Proteins

Alpha Synuclein Pre-formed Fibrils (PFFs) 

StressMarq’s alpha synuclein pre-formed fibrils (PFFs) seed the formation of new fibrils from active alpha synuclein monomers, and can be used to induce endogenous alpha synuclein phosphorylation and subsequent Lewy body inclusion formation in neuronal cell culture or for in vitro oligomerization studies.

Product Description Catalog# Monomer Source
Human Alpha Synuclein Pre-formed Fibrils (Type 1) SPR-322 Human Alpha Synuclein Monomers, catalog# SPR-321
Human Alpha Synuclein Pre-formed Fibrils (ATTO 594 conjugated, Type 1) SPR-322-A594 Human Alpha Synuclein Monomers, catalog# SPR-321
Mouse Alpha Synuclein Pre-formed Fibrils (Type 1) SPR-324 Mouse Alpha Synuclein Monomers, catalog# SPR-323
Human Alpha Synuclein Pre-formed Fibrils (Type 2) SPR-317 Human Alpha Synuclein Monomers (Type 2), catalog# SPR-316
Human Alpha Synuclein N-Terminal Acetylated Pre-formed Fibrils (Type 1) SPR-332 Human N-Terminal Acetylated Alpha Synuclein Monomers, catalog# SPR-331
Human Alpha Synuclein A53T Mutant Pre-formed Fibrils (Type 1) SPR-326 Human A53T Alpha Synuclein Monomers (Type 1), catalog# SPR-325
Rat Alpha Synuclein Pre-formed Fibrils SPR-482 Rat Alpha Synuclein Monomers, catalog# SPR-481
Human Alpha Synuclein Filaments (Immature Fibrils) SPR-450 Human Alpha Synuclein Monomers, catalog# SPR-321

Alpha Synuclein Oligomers 

Alpha synuclein oligomers are increasingly thought to be the toxic species in synucleinopathies. StressMarq’s kinetically stable alpha synuclein oligomers are toxic to dopaminergic neurons and induce phosphorylation of alpha synuclein Ser129 (a pathology associated with Parkinson’s disease), and are generated without the addition of any inducers or inhibitors.  StressMarq also offers dopamine-stabilized alpha synuclein oligomers and EGCG-stabilized alpha synuclein oligomers. Dopamine and EGCG can be used to stabilize alpha synuclein in its oligomeric forms, preventing further aggregation into fibrils.

Product Description Catalog# Monomer Source
Human Alpha Synuclein Oligomers (Kinetically Stable) SPR-484 Human Alpha Synuclein Monomers (Type 2), catalog# SPR-316
Human Alpha Synuclein Oligomers (Dopamine HCl Stabilized) SPR-466 Human Alpha Synuclein Monomers (Type 2), catalog# SPR-316
Human Alpha Synuclein Oligomers (EGCG Stabilized) SPR-469 Human Alpha Synuclein Monomers (Type 2), catalog# SPR-316

Alpha Synuclein Monomers 

StressMarq’s alpha synuclein monomers are capable of aggregation and do not show neurodegenerative activity.

Product Description Catalog#
Human Alpha Synuclein Monomers (Type 1) SPR-321
Human Alpha Synuclein Monomers (Type 2) SPR-316
Mouse Alpha Synuclein Monomers (Type 1) SPR-323
Human Alpha Synuclein A53T Mutant Monomers (Type 1) SPR-325
Human Alpha Synuclein N-Terminal Acetylated Monomers (Type 1) SPR-331
Rat Alpha Synuclein Monomers SPR-481

Parkinson’s Disease Small Molecules

FPS-ZM1

Pinacidil Monohydrate

Rasagiline Mesylate

Tolcapone

Parkinson’s Disease Kits

Nitrotyrosine ELISA Kit